How Well Evolved Is The Folding Code?

How well can simulation predict protein folding kinetics and thermodynamics?

Simulation of protein folding has come a long way in five years. Notably, new quantitative comparisons with experiments for small, rapidly folding proteins have become possible. As the only way to validate simulation methodology, this achievement marks a significant advance. Here, we detail these recent achievements and ask whether simulations have indeed rendered quantitative predictions in se...

How is the Mother Tongue Acquired

How optimal is the genetic code?

The genetic code is well-known to be fault tolerant, in the sense that transcription errors in the third codon position frequently do not influence the amino acid expressed, while errors in other codon positions often lead to amino acids having similar chemical properties. Several articles in the recent past ([?, ?, ?] etc.) have studied the question of optimality of the genetic code. In [?] Di...

Ebola: How well is the UK prepared?

The government expects a handful of cases of Ebola virus disease in the UK over the next three months and it hopes, through screening at airports and other points of entry, to identify passengers coming from the affected region (there are no direct flights and fewer than 1000 arrived via flights from other European capitals in September) who could develop the disease once in the UK, even if the...

[How well-informed is the ophthalmology patient?].

BACKGROUND The patient responsibility concept is based on better informed patients who can shoulder the responsibility for their own health and who can discuss matters competently with their health care provider, becoming partners of their doctors in enabling them to make informed decisions about their medical care. Better patient information and more active participation is also often associat...